TReNDS

open source software

TReNDS develops, applies, and shares advanced analytic approaches and neuroinformatics tools that turn brain imaging, omics, and large-scale data into discoveries for brain health and disease.

Neuroimaging Discovery

We build methods that help researchers study brain structure, function, and dynamics across clinical and nonclinical populations.

Data Fusion

We connect multimodal brain imaging, omics, and machine learning to reveal patterns that single datasets cannot show alone.

Open Collaboration

We share software, data practices, and neuroinformatics tools through a collaborative center across GSU, Georgia Tech, and Emory.

We publish the results of our research as open-source software and research platforms. Below is a selection of tools from TReNDS for neuroimaging analysis, multimodal data fusion, simulation, machine learning, and brain connectivity research.

Desktop application

NeuroFLAME

Neuroimaging Federated Learning Analysis for Multi-site Environments, a GUI-based standalone application

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Analysis Toolbox

4D FFT Toolbox

Computes spatio-spectral temporal profiles for 4D imaging data.

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Connectivity

Average Sliding Window

Simulation code and examples for average sliding window correlation in dynamic functional connectivity.

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Python Package

brainbow

Visualizes ICA components and ROI brain parcellations from NIfTI maps.

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Web Platform

Brainchop

Browser-based brain image segmentation for working with imaging models and segmentation workflows directly on the web.

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Command Line

brainchop

A separate Python package for running Brainchop workflows from the command line.

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PyTorch Framework

Catalyst Neuro

PyTorch framework for deep learning research and development.

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Deep Learning

Cortex

A framework for training and evaluating neural networks using Theano.

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Simulation Toolbox

fMRI Simulation Toolbox (SimTB)

Generates flexible fMRI datasets under a model of spatiotemporal separability for testing analysis methods.

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MATLAB Toolbox

Functional Network Connectivity (FNC)

Finds and displays temporal relationships among components to help study causal relations in the brain.

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MATLAB Toolbox

Fusion ICA Toolbox (FIT)

Supports joint ICA, parallel ICA, and CCA with joint ICA for examining shared information across imaging, EEG, and genetic features.

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MATLAB Toolbox

Group ICA Toolbox (GIFT and EEGIFT)

Implements multiple algorithms for independent component analysis and blind source separation of group and single-subject fMRI and EEG data.

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MATLAB Toolbox

Group Inter-participant Correlation (GIPC)

Compares spatial activation similarities among subjects and across study groups.

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Machine Learning

IRVI

Implements iterative refinement of the approximate posterior for directed belief networks.

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MATLAB Toolbox

Laterality User Interface (LUI)

Generates lateral difference maps from brain images for laterality-focused analysis.

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Analysis Toolbox

MANCOVAN

Tools for multivariate analysis in neuroimaging research workflows.

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Segmentation

MeshNet

Torch implementation of the MeshNet architecture and trained weights for white and gray matter segmentation.

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Python Package

mindfultensors

Builds dataloaders for MRI tensors and segmentation labels stored across MongoDB records.

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PyTorch Implementation

MISA-pytorch

PyTorch implementation for Multidataset Independent Subspace Analysis.

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Deep Learning

Pl2mind

Extends Pylearn2 for neuroimaging and brain data applications, including datasets for incorporating 3D brain data into deep models.

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Python Package

polyssifier

Runs many classifiers on a dataset and produces AUC reports for comparing model performance.

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Simulation

SIMEEG

EEG simulation scripts for generating and testing EEG analysis workflows.

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Simulation

sMRI Simulator

Simulates structural MRI data and includes an example simulation notebook.

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MATLAB Toolbox

Square-root Cubature Kalman Filter (SCKS)

Contains implementations of the square-root Cubature Kalman Filter and square-root Rauch-Tang-Striebel smoother.

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MATLAB Toolbox

Wavelet Denoising Toolbox (WaveIDioT)

Provides improved 3D denoising of fMRI datasets using a wavelet-based hierarchical approach.

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Python Package

wirehead

Caches and serves synthetic data generator output through MongoDB-backed datasets.

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